Difference Between Nephrotic and Nephritic Syndrome


Kidney disorders can manifest in various ways, each with its own set of symptoms, causes, and treatment approaches. Two common kidney conditions that are often confused are nephrotic syndrome and nephritic syndrome. While both conditions affect the kidneys, they have distinct characteristics and require different management strategies. In this comprehensive guide, we’ll delve into the differences between nephrotic syndrome and nephritic syndrome, providing valuable insights for patients, caregivers, and healthcare professionals alike.

Nephrotic Syndrome: Overview

Nephrotic syndrome is a kidney disorder characterized by excessive proteinuria (protein in the urine), hypoalbuminemia (low levels of albumin in the blood), edema (swelling), and hyperlipidemia (high levels of lipids in the blood). It typically results from damage to the glomeruli, the filtering units of the kidneys, leading to increased permeability of the glomerular membrane and leakage of protein into the urine.

Key Features of Nephrotic Syndrome:

  1. Proteinuria: Excretion of large amounts of protein (>3.5 grams per day) in the urine.
  2. Hypoalbuminemia: Decreased levels of albumin in the blood, leading to fluid accumulation in the tissues.
  3. Edema: Swelling, particularly in the lower extremities, abdomen, and face, due to fluid retention.
  4. Hyperlipidemia: Elevated levels of cholesterol and triglycerides in the blood, contributing to lipiduria (lipids in the urine).

Nephritic Syndrome: Overview

Nephritic syndrome, on the other hand, is characterized by inflammation of the glomeruli, often resulting from immune-mediated processes such as glomerulonephritis. Unlike nephrotic syndrome, nephritic syndrome is associated with hematuria (blood in the urine), hypertension (high blood pressure), and oliguria (decreased urine output), reflecting the acute inflammatory nature of the condition.

Key Features of Nephritic Syndrome:

  1. Hematuria: Presence of red blood cells in the urine, which may be visible (macroscopic hematuria) or detected under a microscope (microscopic hematuria).
  2. Hypertension: Elevation of blood pressure, often due to sodium and fluid retention and activation of the renin-angiotensin-aldosterone system.
  3. Oliguria: Reduced urine output, resulting from decreased glomerular filtration rate and impaired kidney function.
  4. Proteinuria: While proteinuria is a hallmark feature of nephrotic syndrome, it may also be present in nephritic syndrome, although typically to a lesser extent.

Causes and Pathophysiology

Nephrotic Syndrome:

  • Primary Causes: Minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy.
  • Secondary Causes: Diabetes mellitus, systemic lupus erythematosus, amyloidosis, infections, medications.
  • Pathophysiology: Damage to the glomerular filtration barrier, leading to increased permeability to proteins and subsequent proteinuria and edema.

Nephritic Syndrome:

  • Primary Causes: Acute post-infectious glomerulonephritis, IgA nephropathy, rapidly progressive glomerulonephritis.
  • Secondary Causes: Systemic infections (e.g., streptococcal infection), autoimmune disorders, vasculitis.
  • Pathophysiology: Immune-mediated inflammation of the glomeruli, resulting in damage to the glomerular basement membrane, hematuria, and reduced kidney function.

Diagnosis and Evaluation

Nephrotic Syndrome:

  • Urinalysis: Presence of heavy proteinuria (>3.5 grams/day), often with lipiduria.
  • Serum Albumin: Decreased levels of serum albumin (<3.5 g/dL), indicating hypoalbuminemia.
  • Serum Lipids: Elevated levels of cholesterol and triglycerides.
  • Renal Biopsy: Often required to confirm the underlying cause and guide treatment decisions.

Nephritic Syndrome:

  • Urinalysis: Presence of hematuria, often with red blood cell casts and varying degrees of proteinuria.
  • Serum Creatinine: Elevated serum creatinine levels, reflecting impaired kidney function.
  • Blood Pressure Measurement: Hypertension is a common feature of nephritic syndrome.
  • Serological Tests: Antistreptolysin O (ASO) titer, complement levels, and autoantibodies may be indicative of specific underlying causes.

Treatment Approaches

Nephrotic Syndrome:

  • Immune-Suppressive Therapy: Corticosteroids, immunosuppressants (e.g., cyclophosphamide, tacrolimus) for primary causes.
  • Angiotensin-Converting Enzyme (ACE) Inhibitors or Angiotensin II Receptor Blockers (ARBs): To control blood pressure and reduce proteinuria.
  • Dietary Modifications: Low-sodium diet, protein restriction (in severe cases), and lipid-lowering agents for hyperlipidemia.

Nephritic Syndrome:

  • Treatment of Underlying Cause: Antibiotics for post-infectious glomerulonephritis, immunosuppressive therapy for autoimmune causes.
  • Blood Pressure Control: Antihypertensive medications (e.g., ACE inhibitors, calcium channel blockers) to manage hypertension.
  • Dietary Modifications: Low-sodium diet to reduce fluid retention and hypertension.
  • Supportive Care: Fluid and electrolyte management, monitoring for complications such as acute kidney injury and nephrotic syndrome.

Prognosis and Complications

Nephrotic Syndrome:

  • Prognosis: Variable depending on the underlying cause and response to treatment.
  • Complications: Malnutrition, infections, thromboembolism, end-stage renal disease (in severe cases).

Nephritic Syndrome:

  • Prognosis: Depends on the underlying cause, severity of kidney injury, and response to treatment.
  • Complications: Acute kidney injury, chronic kidney disease, hypertension-related complications, and renal failure in severe cases.


Nephrotic syndrome and nephritic syndrome are distinct kidney disorders with unique clinical features, underlying causes, and treatment approaches. While nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, and edema, nephritic syndrome presents with hematuria, hypertension, and reduced kidney function. Accurate diagnosis and timely intervention are essential for optimizing outcomes and preventing complications in patients with these conditions. For individuals experiencing symptoms suggestive of kidney disease, consulting a kidney specialist doctor for evaluation and management is crucial. With proper diagnosis, personalized treatment, and ongoing care, individuals with nephrotic syndrome and nephritic syndrome can effectively manage their condition and improve their quality of life.

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